Departmental Publications

2021 Publications

USMLE Step-1 is Going to Pass/Fail, Now What Do We Do? Belovich AN, Bahner I, Bonaminio G, Brenneman A, Brooks WS, Chinn C, El-Sawi N, Haight M, Haudek SB, Ikonne U, McAuley RJ, McKell D, Rowe R, Taylor TAH, Vari RC. Med Sci Educ. 2021 Jun 4:1-6.

Physician Beliefs Concerning Structural and Institutional Racism in Health Care. Ciurylo W, Brenner CA,Thieme VS. Osteopathic Family Physician. 2021 May/June; Volume 13, Issue 3.

Primary Small Cell Carcinoma of the Bladder. Kassas JM, Fiuk JV, Brenner CA. Cureus. 2021 May 21;13(5):e15146.

Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels. Payne E, Harrington K, Richard P, Brackin R, Davis R, Couture S, Liff J, Asmus F, Mutina E, Fisher A, Giuvelis D, Sannajust S, Rostama B, King T, Mattei LM, Lee JJ, Friedman ES, Bittinger K, May M, Stevenson GW. J Pain. 2021 May 21:S1526-5900(21)00234-0.

The transition zone protein AHI1 regulates neuronal ciliary trafficking of MCHR1 and its downstream signaling pathway. Hsiao YC, Muñoz-Estrada J, Tuz K, Ferland RJ. J Neurosci. 2021 Mar 18: 41(17) 3932-3943. doi: 10.1523/JNEUROSCI.2993-20.2021. FEATURED ARTICLE IN ISSUE 41(17) with write-up being found here.

Admissions During the COVID-19 Pandemic: Navigating an Altered Landscape for Successful Selection of Future Healthcare Providers. Belovich AN, Bahner I, Bonaminio G, Brenneman A, Brooks WS, Chinn C, El-Sawi N, Haight M, Haudek SB, McAuley RJ, McKell D, Rowe R, Taylor TAH, Slivkoff MD, Vari RC. Med Sci Educ. 2021 Feb 23:1-4.

Emerging Infectious Diseases at the Clinic-Clinical Lab-Research Lab Interface. Anastasio N, Green E, Pettit S, May M. Annals of Pub Health Rep. 2021; 5(1):142-145.

Regulation of mitochondrial function by Epac2 contributes to acute inflammatory hyperalgesia. Goode DJ and Molliver DCJ Neurosci. 2021; 41(13):2883-2898.

Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart. Prakoso D, Lim SY, Erickson JR, Wallace RS, Lees JG, Tate M, Kiriazis H, Donner DG, Henstridge DC, Davey JR, Qian H, Deo M, Parry LJ, Davidoff AJ, Gregorevic P, Chatham JC, De Blasio MJ, Ritchie RH. Cardiovasc Res. 2021.

The neural basis of attentional alterations in prenatally protein malnourished rats. Rushmore RJ, McGaughy JA, Amaral AC, Mokler DJ, Morgane PJ, Galler JR, Rosene DL. Cereb Cortex. 2021; 31(1):497-512.

Effectiveness of Educating Health Care Professionals in Managing Chronic Pain Patients Through a Supervised Student Inter-professional Pain Clinic. Cao L, Hull SZ. Med Sci Educ. 2021; Jan 13. 

2020 Publications

Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration.  Stefanucci A, Dimmito MP, Macedonio G, Ciarlo L, Pieretti S, Novellino E, Lei W, Barlow D, Houseknecht KL, Streicher JM, Mollica A.  J Med Chem. 2020; 63(5):2673-2687.

Phenotypic diversity in an emerging mycoplasmal disease.  Perez K, Mullen N, Canter JA, Ley DH, May MMicrob Pathog. 2020; 103798.

AutoSholl allows for automation of Sholl analysis independent of user tracing.  Srinivasan A, Srinivasan A, Ferland RJ.  J Neurosci Methods. 2020; 331:108529.

Exploring mechanisms of increased cardiovascular disease risk with antipsychotic medications: Risperidone alters the cardiac proteomic signature in mice.  Beauchemin M, Geguchadze R, Guntur AR, Nevola K, Le PT, Barlow D, Rue M, Vary CPH, Lary CW, Motyl KJ, Houseknecht KL.  Pharmacol Res. 2020; 152:104589. 

Characterizing the Mechanical Properties of Ectopic Axonal Receptive Fields in Inflamed Nerves and Following Axonal Transport Disruption.  Goodwin G, Bove GM, Dayment B, Dilley A.  Neuroscience. 2020; 429:10-22.

Osteopathic Manipulative Treatment for Low Back Pain.  Ponna V, Talsma J, Pierce-Talsma S.  J Am Osteopath Assoc. 2020; 120(6):e84-e85. 

Noninvasive Electrocardiography in the Perinatal Mouse.  Fitzsimons LA, Brewer VL, Forrester J, Moran AM, Tucker KL.  J Vis Exp. 2020; 160:e61074.

Hypertension: An Osteopathic Perspective.  Prieto H, Pena N, Shubrook JH, Talsma J.  The AAO Journal. 2020; 30(2): 27-34.

Effects of HIV gp120 on Neuroinflammation in Immunodeficient vs. Immunocompetent States.   Arabatzis TJ, Wakley AA, McLane VD, Canonico D, Cao L.  J Neuroimmune Pharmacol. 2020.   

Antipsychotic-induced immune dysfunction: A consideration for COVID-19 risk.  May M, Slitzky M, Rostama B, Barlow D, Houseknecht KL.  Brain Behav Immun Health. 2020; 6:100097. 

Synthesis and Structure-Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects.  Vekariya RH, Lei W, Ray A, Saini SK, Zhang S, Molnar G, Barlow D, Karlage KL, Bilsky EJ, Houseknecht KL, Largent-Milnes TM, Streicher JM, Ananthan S.  J Med Chem. 2020; 63(14):7663-7694.

Evaluation of Using the Sphygmomanometer Test to Assess Pain Sensitivity in Chronic Pain Patients vs Normal Controls.  Butler S, Draleau K, Heinrich R, Nguyen L, Shbeeb D, Sigalovsky D, Koh W, Hull SZ, Cao L.  Pain Med. 2020; 21(11):2903–2912.

Osteopathic Manipulative Treatment for Inhaled Rib Somatic Dysfunction.  Koch J, Tsui C, Talsma J, Pierce-Talsma S.  J Am Osteopath Assoc. 2020 Jul 28.   

Deletion of α-Synuclein in Prrx1-positive cells causes partial loss of function in the central nervous system (CNS) but does not affect ovariectomy induced bone loss.  Figueroa CA, Bajgain P, Stohn JP, Hernandez A, Brooks DJ, Houseknecht KL, Rosen CJ.  Bone. 2020; 137:115428. 

Research at University of New England College of Osteopathic Medicine.  Brenner CA.  J Am Osteopath Assoc. 2020; 120(8):495-496. 

Learning Together: Interprofessional Education at the University of New England.  Mokler DJ, Konrad SC, Hall K, Rodriguez K, St Pierre S, Thieme VS, Van Deusen J.  J Am Osteopath Assoc. 2020; 120(8):509-515.

Making the Connection: Using Concept Mapping to Bring the Basic Sciences to the Diagnosis.  Spicer DBThompson KHKilgallen SM.  J Am Osteopath Assoc. 2020; 120(8):524-528. 

Report on 7 Years’ Experience Implementing an Undergraduate Medical Curriculum for Osteopathic Medical Students Using Entrustable Professional Activities.  Reynolds TS, Frothingham C, Carreiro JE, Branda A, Schuenke MDTucker KLDaly FWillard FH.  J Am Osteopath Assoc. 2020; 120(8):529-539.

Overview of the Pathogenesis and Treatment of SARS-CoV-2 for Clinicians: A Comprehensive Literature Review.  Voto C, Berkner P, Brenner C.  Cureus. 2020; 12(9):e10357. 

Association of Beta Blocker Use With Bone Mineral Density in the Framingham Osteoporosis Study: A Cross-Sectional Study. Lary CW, Hinton AC, Nevola KT, Shireman TI, Motyl KJ, Houseknecht KL, Lucas FL, Hallen S, Zullo AR, Berry SD, Kiel DP. JBMR Plus. 2020; 4(9):e10388.

Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors. Mecum NE, Demers D, Sullivan CE, Denis TE, Kalliel JR, Meng ID. Sci Rep. 2020 Oct 14;10(1):17225.

Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV. Pain. 2020 Oct 15.

Evolution and Revolution in Medical Education: Health System Sciences (HSS). Rowe RJ, Bahner I, Belovich AN, Bonaminio G, Brenneman A, Brooks WS, Chinn C, El-Sawi N, Haudek SB, Haight M, McAuley R, Slivkoff MD, Vari RC. Med Sci Edu. 2020; 16:1-6. 

Effects of the Covid-19 Pandemic on “The Big Three”: HIV, Tuberculosis, and Malaria. May M. Annals of Public Health Reports. 2020; 4(1).

Understanding Mechanisms Underlying Non-Alcoholic Fatty Liver Disease (NAFLD) in Mental Illness: Risperidone and Olanzapine Alter the Hepatic Proteomic Signature in Mice. Rostama B, Beauchemin M, Bouchard C, Bernier E, Vary CPH, May MHouseknecht KL. Int J Mol Sci. 2020; 21(24):E9362. 

The enduring effect of prenatal protein malnutrition on brain anatomy, physiology and behavior. Rushmore RJ, McGaughy JA, Mokler DJ, Rosene DL.  Nutr Neurosci. 2020: 1-8.

2019 Publications

Medical biochemistry without rote memorization: multi-institution implementation and student perceptions of a nationally standardized metabolic map for learning and assessment.  Spicer DBThompson KH, Tong M, Cowan TM, Fulton TB, Lindsley JE. Med Sci Edu. 2019; 29(1):87-92.

Prenatal Protein Malnutrition Produces Resistance to Distraction Similar to Noradrenergic Deafferentation of the Prelimbic Cortex in a Sustained Attention Task.  Newman LA, Baraiolo J, Mokler DJ, Rabinowitz AG, Galler JR, McGaughy JA.  Front Neurosci. 2019; 13:123.

Manual therapy prevents onset of nociceptor activity, sensorimotor dysfunction, and neural fibrosis induced by a volitional repetitive task.  Bove GM, Delany SP, Hobson L, Cruz GE, Harris MY, Amin M, Chapelle SL, Barbe MF.  Pain. 2019; 160(3):632-644.

Prenatal Protein Malnutrition Leads to Hemispheric Differences in the Extracellular Concentrations of Norepinephrine, Dopamine and Serotonin in the Medial Prefrontal Cortex of Adult Rats.  Mokler DJ, McGaughy JA, Bass D, Morgane PJ, Rosene DL, Amaral AC, Rushmore RJ, Galler JR.  Front Neurosci. 2019; 13:136.

Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs.  Harrison BJ, Park JW, Gomes C, Petruska JC, Sapio MR, Iadarola MJ, Chariker JH, Rouchka EC.  Front Genet. 2019; 10:182. 

A lesson from classic British literature.  Bove GM, Dilley A.  Lancet. 2019; 393(10178):1297-1298.

Loss of the neurodevelopmental Joubert syndrome causing protein, Ahi1, causes motor and muscle development delays independent of central nervous system involvement.  Bourgeois JR, Ferland RJ.  Dev Biol. 2019; 448(1):36-47. 

Progesterone Application to the Rat Forehead Produces Corneal Antinociception.  Meng ID, Barton ST, Goodney I, Russell R, Mecum NE.  Invest Ophthalmol Vis Sci. 2019; 60(5):1706-1713.

Role of Evolutionary Selection Acting on Vaccine Antigens in the Re-Emergence of Bordetella Pertussis.  Etskovitz H, Anastasio N, Green E, May M.  Diseases. 2019; 7(2):35.

Pros and Cons of Clinically Relevant Methods to Assess Pain in Rodents.  Tappe-Theodor A, King T, Morgan MM.  Neurosci Biobehav Rev. 2019; 100:335-343. 

Phospho-substrate profiling of Epac-dependent protein kinase C activity.  Goode DJ, Molliver DC.  Mol Cell Biochem. 2019; 456(1-2):167-178.

Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1.  Hatta A, Kurose M, Sullivan C, Okamoto K, Fujii N, Yamamura K, Meng ID.  J Neurophysiol. 2019; 121(6):2191-2201. 

Mechanism of Microbicidal Action of E-101 Solution, a Myeloperoxidase-Mediated Antimicrobial, and Its Oxidative Products.  Denys GA, Devoe NC, Gudis P, May M, Allen RC, Stephens JT Jr.  Infect Immun. 2019; 87(7):e00261-19.

The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice.  May M, Beauchemin M, Vary C, Barlow D, Houseknecht KL.  PLoS One. 2019; 14(6):e0218937. 

Form and Force Closure of the Sacroiliac Joints.  Vleeming A, Schuenke M.  PM R. 2019; 11(Suppl 1):S24-S31.

Evaluation of Corneal Damage After Lacrimal Gland Excision in Male and Female Mice.  Mecum NE, Cyr D, Malon J, Demers D, Cao LMeng ID.  Invest Ophthalmol Vis Sci. 2019; 60(10):3264-3274. 

Recommended rejection of the names Malacoplasma gen. nov., Mesomycoplasma gen. nov., Metamycoplasma gen. nov., Metamycoplasmataceae fam. nov., Mycoplasmoidaceae fam. nov., Mycoplasmoidales ord. nov., Mycoplasmoides gen. nov., Mycoplasmopsis gen. nov. [Gupta, Sawnani, Adeolu, Alnajar and Oren 2018] and all proposed species comb. nov. placed therein.  Balish M, Bertaccini A, Blanchard A, Brown D, Browning G, Chalker V, Frey J, Gasparich G, Hoelzle L, Knight T, Knox C, Kuo CH, Manso-Silván L, May M, Pollack JD, Ramírez AS, Spergser J, Taylor-Robinson D, Volokhov D, Zhao Y.  Int J Syst Evol Microbiol. 2019; 69(11):3650-3653.

The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.  Fujiwara M, Tian L, Le PT, DeMambro VE, Becker KA, Rosen CJ, Guntur AR.  J Biol Chem. 2019; 294(34):12683-12694.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Gurumurthy CB, O’Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D’Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G.  Genome Biol. 2019; 20(1):171. 

Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain.  Sannajust S, Imbert I, Eaton V, Henderson T, Liaw L, May M, Barbe MF, King T.  Pain. 2019; 160(9):2036-2049. 

Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration.  Muñoz-Estrada J, Ferland RJ.  J Cell Sci. 2019; 132(17):jcs230680.

Neuropathy and neural plasticity in the subcutaneous white adipose depot.  Blaszkiewicz M, Willows JW, Dubois AL, Waible S, DiBello K, Lyons LL, Johnson CP, Paradie E, Banks N, Motyl K, Michael M, Harrison B, Townsend KL.  PLoS One. 2019; 14(9):e0221766. 

TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms.  Knight BE, Kozlowski N, Havelin J, King T, Crocker SJ, Young EE, Baumbauer KM.  Front Mol Neurosci. 2019; 12:220. 

Polymicrobial abscess following ovariectomy in a mouse.   Eaton VE, Pettit S, Elkinson A, Houseknecht KLKing TEMay M.  BMC Vet Res. 2019; 15(1):364. 

Population imaging of neural activity in awake behaving mice.  Piatkevich KD, Bensussen S, Tseng HA, Shroff SN, Lopez-Huerta VG, Park D, Jung EE, Shemesh OA, Straub C, Gritton HJ, Romano MF, Costa E, Sabatini BL, Fu Z, Boyden ES, Han X.  Nature. 2019; 574(7778):413-417. 

Advancing Nutrition Education, Training, and Research for Medical Students, Residents, Fellows, Attending Physicians, and Other Clinicians: Building Competencies and Interdisciplinary Coordination.  Van Horn L, Lenders CM, Pratt CA, Beech B, Carney PA, Dietz W, DiMaria-Ghalili R, Harlan T, Hash R, Kohlmeier M, Kolasa K, Krebs NF, Kushner RF, Lieh-Lai M, Lindsley J, Meacham S, Nicastro H, Nowson C, Palmer C, Paniagua M, Philips E, Ray S, Rose S, Salive M, Schofield M, Thompson K, Trilk JL, Twillman G, White JD, Zappalà G, Vargas A, Lynch C.  Adv Nutr. 2019; 10(6):1181-1200.

A Novel Mechanism for Zika Virus Host-Cell Binding.  Rieder CA, Rieder J, Sannajust S, Goode DGeguchadze R, Relich RF, Molliver DCKing TEVaughn JMay M.  Viruses. 2019; 11(12):1101.

Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability: Implications for Healing. Brezinski M, Willard F, Rupnick M.  Circulation. 2019; 140(23):1857-1859.

Transcriptional and pathological host responses to co-infection with virulent or attenuated Mycoplasma gallisepticum and low pathogenic avian influenza A virus in chickens.  Canter JA, Tulman ER, Beaudet J, Lee D, May M, Szczepanek SM, Geary SJ.  Infect Immun. 2019; 88(1): e00607-19.

Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s Disease.  Mustafa R, Kreiner G, Kamińska K, Wood AJ, Kirsch J, Tucker KL, Parlato R.  Front Cell Neurosci. 2019; 13:565. 

RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats.  Huynh PN, Giuvelis D, Christensen S, Tucker KL, McIntosh JM.  Mar Drugs. 2019; 18(1):12.