{"id":1619,"date":"2020-08-10T13:32:11","date_gmt":"2020-08-10T13:32:11","guid":{"rendered":"https:\/\/sites.une.edu\/research\/?p=1619"},"modified":"2020-08-19T16:00:39","modified_gmt":"2020-08-19T16:00:39","slug":"virtual-undergraduate-research-in-medicinal-chemistry","status":"publish","type":"post","link":"https:\/\/sites.une.edu\/research\/virtual-undergraduate-research-in-medicinal-chemistry\/","title":{"rendered":"Virtual undergraduate research in Medicinal Chemistry"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sites.une.edu\/research\/wp-content\/uploads\/sites\/20\/2020\/08\/noah-garrison-2.png\" alt=\"\" class=\"wp-image-1621\" width=\"237\" height=\"235\" \/><\/figure><\/div>\n\n\n\n<p>Organic Chemist Dr. Amy Deveau initiated a new virtual research collaboration this summer with Dr. George Shields, professor of chemistry at Furman University. &nbsp; The project focused on developing a compound database for a computational model to better understand antagonism at the mu opioid receptor (MOR). The MOR is involved in biochemical pathways of pain and addiction.&nbsp;<\/p>\n\n\n\n<p>Dr. Deveau\u2019s research student Noah Garrison, a senior biochemistry major, was funded by an award to Dr. Deveau from UNE\u2019s Research Infrastructure Fund via the Office of Research and Scholarship.&nbsp; The monies enabled Noah to train with Schrodinger Corporation\u2019s Maestro software which will be utilized for the computational aims of the project. &nbsp; Noah also received support from the Center of Excellence in Neuroscience.&nbsp; &nbsp; &nbsp;<\/p>\n\n\n\n<p>Dr. Shields\u2019 efforts were funded by NIH-INBRE, through the&nbsp;2020 INBRE Faculty Fellows Summer Research program.&nbsp;The grant funded two Furman neuroscience students, rising juniors Lauren Jones and Brenna Outten, as well as providing funding for molecular modeling software.&nbsp;<\/p>\n\n\n\n<p>The image was made by Noah Garrison using software by Schrodinger on which Noah received training this summer.&nbsp; The image shows molecular interactions of the morphine-like agonist BU72 (green) bound to the mu opioid receptor (X-ray structure 5C1M).<\/p>\n\n\n\n<p>Visualizing agonist and antagonist interactions with the MOR is helping the Deveau research group better understand ways to improve binding efficacy of MOR agents.<\/p>\n\n\n\n<p>This training was supported by the Office of Research and Scholarship RIF award to Dr. Deveau.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Organic Chemist Dr. Amy Deveau initiated a new virtual research collaboration this summer with Dr. George &hellip;<\/p>\n","protected":false},"author":49,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[],"post_folder":[],"class_list":["post-1619","post","type-post","status-publish","format-standard","hentry","category-student-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/1619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/comments?post=1619"}],"version-history":[{"count":3,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/1619\/revisions"}],"predecessor-version":[{"id":1794,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/1619\/revisions\/1794"}],"wp:attachment":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/media?parent=1619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/categories?post=1619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/tags?post=1619"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/post_folder?post=1619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}