{"id":5708,"date":"2021-10-15T08:52:47","date_gmt":"2021-10-15T13:52:47","guid":{"rendered":"https:\/\/sites.une.edu\/research\/?p=5708"},"modified":"2021-10-15T08:52:47","modified_gmt":"2021-10-15T13:52:47","slug":"glenn-stevenson-recently-published-a-paper-on-gut-microbiome-modulation-of-inflammatory-pain-co-authored-by-ten-current-and-former-une-undergraduate-students-in-the-journal-of-pain","status":"publish","type":"post","link":"https:\/\/sites.une.edu\/research\/glenn-stevenson-recently-published-a-paper-on-gut-microbiome-modulation-of-inflammatory-pain-co-authored-by-ten-current-and-former-une-undergraduate-students-in-the-journal-of-pain\/","title":{"rendered":"Glenn Stevenson recently published a paper on gut microbiome modulation of inflammatory pain co-authored by ten current and former UNE undergraduate students in The Journal of Pain."},"content":{"rendered":"\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/34029686\/<\/a><\/p>\n\n\n\n

Glenn Stevenson, Ph.D., professor of psychology, recently published a paper on gut microbiome modulation of inflammatory pain co-authored by ten current and former UNE undergraduate students.<\/p>\n\n\n\n

The paper, \u201cEffects of vancomycin on persistent pain-stimulated and pain-depressed behaviors in female Fischer rats with or without voluntary access to running wheels<\/strong>\u201d, was published in a high-impact, peer-reviewed journal, The Journal of Pain<\/em>, the journal of The United States Association for the Study of Pain.<\/p>\n\n\n\n

The research paper examines the impact of antibiotics on the gut microbiome and how antibiotic use can alter inflammatory pain in subjects with or without access to exercise.<\/p>\n\n\n\n

Collaborators \/ co-authors included Dr. Elliot Friedman, Ph.D., Penn Perelman School of Medicine Division of Gastroenterology and Drs. Lisa Mattei, Jung-Jin Lee, and Kyle Bittinger from Children\u2019s Hospital of Philadelphia Microbiome Center and Division of Gastroenterology, Hepatology and Nutrition. Additional co-authors included long-term collaborators with the Stevenson Lab \u2013 Meghan May, Ph.D. and Tamara King, Ph.D., from UNE COM.<\/p>\n\n\n\n

According to Stevenson, this is the first publication to assess how antibiotic-induced changes to the gut microbiome impact inflammatory pain distal to the gut (in the limbs for example), using behavioral procedures developed in the Stevenson Lab.<\/p>\n\n\n\n

Results from this study indicate that the glycopeptide antibiotic vancomycin decreases pain-related behaviors and that manipulation of the gut microbiome may be one method to attenuate inflammatory pain amplitude. Additionally, results indicated that a causal mechanism for this reduction in pain may be due to an antibiotic-induced shift in gut amino acid concentrations. The link between amino acids and pain reduction is highly novel. The research for this study took four years to complete.<\/p>\n\n\n\n

The paper was co-authored by ten current and former undergraduate student researchers in Stevenson\u2019s lab. Additionally, first author went to one of Stevenson\u2019s students. Student co-authors were: Emily Payne, \u201819 (Medical Biology); Kylee Harrington, \u201920 (Neuroscience); Philomena Richard, \u201918 (Neuroscience); Rebecca Brackin, \u201819 (Medical Biology); Ravin Davis, \u201821 (Neuroscience); Sarah Couture, \u201918 (Medical Biology); Jacob Liff, \u201919 (Neuroscience); Francesca Asmus, \u201922 (Neuroscience); Elizabeth Mutina, \u201920 (Neuroscience); Anyssa Fisher, \u201919 (Neuroscience).<\/p>\n\n\n\n

Additional co-authors included Denise Giuvelis, B.S., manager of the UNE COBRE Behavior Core, Sebastian Sannajust, B.S., former lab manager to Dr. Tamara King\u2019s, and Bahman Rostama, Ph.D., former post-doctoral fellow in the lab of Dr. Meghan May.<\/p>\n\n\n\n

\u201cThis is another example of the high-quality, high-impact research that our UNE undergraduate students are engaged in daily. These co-authorships go a long way toward securing post-graduate positions for our students\u201d, Stevenson said.<\/p>\n\n\n\n

He also spoke of the interprofessional nature of the research.<\/p>\n\n\n\n

\u201cThis publication represents a highly interdisciplinary research team with expertise in genomics, proteomics, metabolomics, pharmacology, psychology, neuroscience, microbiology and virology (phew!!). When you put all these disciplines together to solve a single problem, you end up doing innovative, creative, and significant work. The main ideas for this research were generated in meetings between me, Meghan, and Tamara. I then reached out to Penn and Children\u2019s Hospital researchers who subsequently joined our group, and the rest is history.\u201d<\/p>\n\n\n\n

Funding for the research was provided by a COBRE Pilot grant to Drs. Stevenson and May, and a Behavioral Core grant to Stevenson.<\/p>\n\n\n\n

Link to the article abstract (full article is in press, and not available yet)<\/p>\n","protected":false},"excerpt":{"rendered":"

https:\/\/pubmed.ncbi.nlm.nih.gov\/34029686\/ Glenn Stevenson, Ph.D., professor of psychology, recently published a paper on gut microbiome modulation of …<\/p>\n","protected":false},"author":49,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[21,26],"tags":[],"post_folder":[],"class_list":["post-5708","post","type-post","status-publish","format-standard","hentry","category-publications-and-awards","category-student-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/5708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/comments?post=5708"}],"version-history":[{"count":2,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/5708\/revisions"}],"predecessor-version":[{"id":5710,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/5708\/revisions\/5710"}],"wp:attachment":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/media?parent=5708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/categories?post=5708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/tags?post=5708"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/post_folder?post=5708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}