{"id":7635,"date":"2022-10-06T19:39:00","date_gmt":"2022-10-07T00:39:00","guid":{"rendered":"https:\/\/sites.une.edu\/research\/?p=7635"},"modified":"2022-10-06T19:39:01","modified_gmt":"2022-10-07T00:39:01","slug":"geoffrey-ganters-laboratory-publishes-in-molecular-pain","status":"publish","type":"post","link":"https:\/\/sites.une.edu\/research\/geoffrey-ganters-laboratory-publishes-in-molecular-pain\/","title":{"rendered":"Geoffrey Ganter&#8217;s Laboratory Publishes in Molecular Pain"},"content":{"rendered":"\n<p>Led by Christine Hale, who recently earned her PhD studying in the Ganter lab as part of the University of Maine&#8217;s Graduate School of Biomedical Sciences and Engineering program, the group showed that pain sensitivity is influenced by the Wnt\/Wingless pathway component Armadillo.\u00a0 When Hale and colleagues increased the level of Armadillo (the <em>Drosophila<\/em> homolog of b-catenin) specifically in the nociceptor, behavioral nociceptive sensitivity was significantly increased.\u00a0 When b-catenin\/Armadillo level was reduced specifically in the nociceptor, behavioral nociceptive sensitivity was significantly reduced.\u00a0 Since b-catenin\/Armadillo is known to have at least two distinct cellular roles including transcriptional control and cell adhesion, future work seeks to determine the details of its possible transcriptional mechanism, and implicate any potential cell adhesion partners, such as epidermal cells, that may play a role in determining nociceptive sensitivity.\u00a0 The goal of the laboratory is to identify regulators of nociceptive sensitivity that may represent targets for novel pain medications.<\/p>\n\n\n\n<p>Dr. Hale was assisted by co-authors Julie Moulton (UNE MS&#8217;20) and Yvonne Otis (UNE BS&#8217;21).&nbsp; The group is currently funded by NIH\/NINDS awards 1R03NS126842 and 2R15NS095195 to G. Ganter.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p>Here is the paper&#8217;s citation:<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35712882\/\">Armadillo regulates nociceptive sensitivity in the absence of injury.<\/a>&nbsp; Hale C, Moulton J, Otis Y, Ganter G.&nbsp; Mol Pain. 2022 Apr;18:17448069221111155. doi: 10.1177\/17448069221111155.PMID:&nbsp;35712882&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"392\" height=\"304\" src=\"https:\/\/sites.une.edu\/research\/wp-content\/uploads\/sites\/20\/2022\/10\/GG.jpg\" alt=\"\" class=\"wp-image-7636\" srcset=\"https:\/\/sites.une.edu\/research\/wp-content\/uploads\/sites\/20\/2022\/10\/GG.jpg 392w, https:\/\/sites.une.edu\/research\/wp-content\/uploads\/sites\/20\/2022\/10\/GG-300x233.jpg 300w, https:\/\/sites.une.edu\/research\/wp-content\/uploads\/sites\/20\/2022\/10\/GG-150x116.jpg 150w\" sizes=\"auto, (max-width: 392px) 100vw, 392px\" \/><\/figure>\n\n\n\n<p>Yellow color indicates Armadillo expression in this <em>Drosophila<\/em> nociceptor.\u00a0 Recent publication from the Ganter Laboratory indicates Armadillo modulates pain sensitivity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Led by Christine Hale, who recently earned her PhD studying in the Ganter lab as part &hellip;<\/p>\n","protected":false},"author":49,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[21],"tags":[],"post_folder":[],"class_list":["post-7635","post","type-post","status-publish","format-standard","hentry","category-publications-and-awards"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/7635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/users\/49"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/comments?post=7635"}],"version-history":[{"count":1,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/7635\/revisions"}],"predecessor-version":[{"id":7637,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/posts\/7635\/revisions\/7637"}],"wp:attachment":[{"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/media?parent=7635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/categories?post=7635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/tags?post=7635"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/sites.une.edu\/research\/wp-json\/wp\/v2\/post_folder?post=7635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}