Faculty

Faculty

Hwyda A. Arafat, MD, PhD
  • Clinical Professor
  • harafat@une.edu
  • Interests: Medical education related to cultural humility, social determinants of health and health care disparities; Curricular modifications as tools for the development of both faculty and students
Kathleen A. Becker, PhD
  • Assistant Professor
  • kbecker3@une.edu
  • Interests: Bone formation and cross-talk between bone, fat, and the nervous system

Publications:

The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.  Fujiwara M, Tian L, Le PT, DeMambro VE, Becker KA, Rosen CJ, Guntur AR.  J Biol Chem. 2019; 294(34):12683-12694.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Gurumurthy CB, O’Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D’Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G.  Genome Biol. 2019; 20(1):171.

Carol A. Brenner, PhD
  • Clinical Professor; Associate Dean for Research
  • cbrenner1@une.edu
  • Interests: Reproductive medicine; rural/underserved medicine

Publications:

Physician Beliefs Concerning Structural and Institutional Racism in Health Care. Ciurylo W, Brenner CA,Thieme VS. Osteopathic Family Physician. 2021 May/June; Volume 13, Issue 3.

Primary Small Cell Carcinoma of the Bladder. Kassas JM, Fiuk JV, Brenner CA. Cureus. 2021 May 21;13(5):e15146.

Research at University of New England College of Osteopathic Medicine.  Brenner CA.  J Am Osteopath Assoc. 2020; 120(8):495-496.

Overview of the Pathogenesis and Treatment of SARS-CoV-2 for Clinicians: A Comprehensive Literature Review.  Voto C, Berkner P, Brenner C.  Cureus. 2020; 12(9):e10357.

Ling Cao, MD, PhD
  • Professor
  • lcao@une.edu
  • Interests: Neuroimmune mechanisms of chronic pain and HIV-associated neurological disorders; Chronic pain related clinical/population studies

Publications:

Effectiveness of Educating Health Care Professionals in Managing Chronic Pain Patients Through a Supervised Student Inter-professional Pain Clinic. Cao L, Hull SZ. Med Sci Educ. 2021; Jan 13.

Effects of HIV gp120 on Neuroinflammation in Immunodeficient vs. Immunocompetent States.   Arabatzis TJ, Wakley AA, McLane VD, Canonico D, Cao L.  J Neuroimmune Pharmacol. 2020.

Evaluation of Using the Sphygmomanometer Test to Assess Pain Sensitivity in Chronic Pain Patients vs Normal Controls.  Butler S, Draleau K, Heinrich R, Nguyen L, Shbeeb D, Sigalovsky D, Koh W, Hull SZ, Cao L.  Pain Med. 2020; 21(11):2903–2912.

Evaluation of Corneal Damage After Lacrimal Gland Excision in Male and Female Mice.  Mecum NE, Cyr D, Malon J, Demers D, Cao LMeng ID.  Invest Ophthalmol Vis Sci. 2019; 60(10):3264-3274.

Frank J. Daly, PhD
  • Associate Professor
  • fdaly@une.edu
  • Interests: Vertebrate retinal biology; Anatomical educational practices

Publications:

Report on 7 Years’ Experience Implementing an Undergraduate Medical Curriculum for Osteopathic Medical Students Using Entrustable Professional Activities.  Reynolds TS, Frothingham C, Carreiro JE, Branda A, Schuenke MDTucker KLDaly FWillard FH.  J Am Osteopath Assoc. 2020; 120(8):529-539.

 

Russell J. Ferland, PhD
  • Professor and Chair
  • rferland2@une.edu
  • Interests: Primary cilia in developmental disorders (e.g., Joubert syndrome and periventricular heterotopia); Genetics and mechanisms of epileptogenesis (epilepsy)

The combined long-term objectives of our research are to better understand the molecular, genetic, and cellular mechanisms causing neurodevelopmental and neurological disorders. Overall, my research interests lie primarily in the study of disorders of brain development and neurological disease, and specifically involve the following areas of investigation:

1) functional analyses of AHI1 and CSPP1, two novel genes which we mapped and cloned in individuals with Joubert syndrome (Ferland et al., Nature Genetics, 2004; Doering et al., J. Comp. Neurol., 2008; Hsiao et al., Hum. Mol. Genet., 2009; Westfall et al., J. Neurosci., 2010; Tuz et al., J. Biol. Chem., 2013; Tuz et al., Am. J. Hum. Genet., 2014; Bourgeois and Ferland, Dev. Biol., 2019; Munoz and Ferland, J. Cell Sci., 2019; Hsiao et al., J. Neurosci., 2021),

2) formation and function of the primary non-motile cilia in development and disease (Hsiao et al., Hum. Mol. Genet., 2009; Westfall et al., J. Neurosci., 2010; Hsiao et al., Cilia, 2012; Tuz et al., J. Biol. Chem., 2013; Tuz et al., Am. J. Hum. Genet., 2014; Hua and Ferland, Cilia, 2017; Hua and Feland, Cell. Mol. Life Sci., 2018; Hua and Ferland, Bioessays, 2018; Bourgeois and Ferland, Dev. Biol., 2019; Munoz and Ferland, J. Cell Sci., 2019; Hsiao et al., J. Neurosci., 2021),

3) genetic and neuroanatomical mechanisms of seizure threshold, seizure propagation,  epileptogenesis, and Sudden Unexplained Death in Epilepsy (SUDEP) (Wilson C, FASEB J, 2021; Ferland et al., G3 Genes, Genom. Genet, 2017; Ferland, 2017; Loscher, Ferland, and Ferraro, Epilepsy and Behavior, 2017; Kadiyala et al., J. Neurosci., 2016; Kadiyala et al., Epil. Res., 2015; Kadiyala et al., PLoS ONE, 2014; Papandrea et al., Exp. Neurol., 2009; Papandrea et al., Epil. Res., 2009; Ferland et al, 1998a,b,c, 1999, 2002a,b, 2003).

 

Selected Publications:

Wilson CS, Dohare P, Orbeta S, Nalwalk, JW, Huang Y, Ferland RJ, Sah R, Scimemi A, Mongin AA. Late adolescence mortality in mice with brain-specific deletion of the volume-regulated anion channel subunit LRRC8A. FASEB J., 35:e21869, 2021.

Hsiao YC, Muñoz-Estrada J, Tuz K, Ferland RJ. The transition zone protein AHI1 regulates neuronal ciliary trafficking of MCHR1 and its downstream signaling pathway. J. Neurosci., 41(17):3932-3943, 2021.

Srinivasan A, Srinivasan A, Ferland RJ. AutoSholl allows for automation of Sholl analysis independent of user tracing. J Neurosci Methods, 331:1-6, 2020.   Source code & compiled version of the algorithm are available at: https://github.com/ferlandlab/AutoSholl

Muñoz-Estrada J and Ferland RJ. Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration. Journal of Cell Science, 132(17): 1-18, 2019.

Bourgeois JR and Ferland RJ.  Loss of the neurodevelopmental Joubert syndrome causing protein, Ahi1, causes motor and muscle development delays independent of central nervous system involvement. Developmental Biology, 448(1): 36-47, 2019.

Hua K and Ferland RJ. Primary cilia reconsidered in the context of ciliopathies: Extraciliary and ciliary functions of cilia proteins converge on a polarity theme? Bioessays, 40, 1700132, 1-11, 2018.

  • This work was highlighted in F1000Prime, 5 Dec, 2018.  

Hua K and Ferland RJ. Primary cilia proteins: ciliary and extraciliary sites and functions Cell. Mol. Life Sci., 75:1521–1540, 2018.

Kaskow BJ, Buttrick TS, Klein H-U, White C, Bourgeois JR, Ferland RJ, Patsopoulos N, Bradshaw EM, De Jager PL, Elyaman W. Multiple sclerosis AHI1 genetic risk promotes IFNγ+ CD4+ T cells. Neurology: Neuroimmunology & Neuroinflammation, 5 (1): 1-10 (e414), 2018.

Srinivasan A, Muñoz-Estrada J, Bourgeois JR, Nalwalk J, Pumiglia K, Sheen V, Ferland RJ. BranchAnalysis2D/3D automates morphometry analyses of branching structures. J Neurosci Methods, 294:1-6, 2018.   Source code & compiled version of the algorithm are available at: https://github.com/ferlandlab/BranchAnalysis2D-3D

Ferland RJ. The repeated flurothyl seizure model in mice. Invited submission.  Bio-Protocol, 7(11):1-12, 2017.  DOI:10.21769/BioProtoc.2309.

Löscher W, Ferland RJ, Ferraro TN. The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy. Epilepsy Behav., 73: 214-235, 2017.

Ferland RJ, Smith J, Papandrea D, Gracias J, Haines L, Kadiyala SB, O’Brien B, Kang EY, Beyer B, Herron BJ. Multidimensional genetic analysis of repeated seizures in the hybrid mouse diversity panel reveals a novel epileptogenesis susceptibility locus. G3 Genes Genom. Genet., 7(8): 2545-2558, 2017.

Hua K and Ferland RJ. Fixation methods can differentially affect ciliary protein immunolabeling. Cilia, 6;5: pp. 1-17, 2017.

Kadiyala SB and Ferland RJ. Dissociation of spontaneous seizures and brainstem seizure thresholds in mice exposed to eight flurothyl-induced generalized seizures. Epilepsia Open, 2(1): 48-58, 2017.

Kadiyala SB, Yannix JQ, Nalwalk JW, Papandrea D, Beyer BS, Herron BJ, Ferland RJ. Eight flurothyl-induced generalized seizures lead to the rapid evolution of spontaneous seizures in mice: a model of epileptogenesis with seizure remission. J. Neurosci., 36(28): 7485-7496, 2016.

Kadiyala SB, Papandrea D, Tuz K, Anderson TM, Jayakumara S, Herron BJ, Ferland RJ. Spatiotemporal differences in the c-fos pathway between C57BL/6J and DBA/2J mice following flurothyl-induced seizures: A dissociation of hippocampal Fos from seizure activity. Epilepsy Res., 109:183-196, 2015.

Hu J, Lu J, Lian G, Ferland RJ, Dettenhofer M, Sheen VL. Formin 1 and Filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum. Mol. Genet., 23(17):4663-4673, 2014.

Kadiyala SB, Papandrea D, Herron BJ, Ferland RJ. Segregation of seizure traits in C57 Black mouse substrains using the repeated-flurothyl model. PLoS ONE 9(3): e90506, 2014.

Tuz K, Bachmann-Gagescu R, O’Day DR, Hua K, Isabella CR, Phelps IG, Stolarski AE, O’Roak BJ, Dempsey JC, Lourenco C, Alswaid A, Bönnemann CG, Medne L, Nampoothiri S, Stark Z, Leventer RJ, Topçu M, Cansu A, Jagadeesh S, Done S, Ishak GE, Glass IA, Shendure J, Neuhauss SC, Haldeman-Englert CR, Doherty D, Ferland RJ. Mutations in CSPP1 cause primary cilia abnormalities and Joubert syndrome with or without Jeune asphyxiating thoracic dystrophy. Am. J. Hum. Genet., 94(1): 62–72, 2014.

Tuz K, Hsiao YC, Juarez O, Shi B, Harmon EY, Phelps IG, Lennartz MR, Glass IA, Doherty D, Ferland RJ. The Joubert syndrome associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactions. J. Biol. Chem., 288(19):13676-94, 2013.

Bhoiwala DL, Koleilat I, Qian J, Beyer B, Hushmendy SF, Mathew A, Bhoiwala DL, Ferland RJ, Crawford DR. Overexpression of RCAN1 isoform 4 in mouse neurons leads to a moderate behavioral impairment. Neurol. Res., 35(1):79-89, 2013.

Zhang J, Neal J, Lian G, Shi B, Ferland RJ, Sheen VL. Brefeldin A-inhibited guanine exchange factor 2 regulates Filamin A phosphorylation and neuronal migration. J. Neurosci., 32(36):12619-12629, 2012.

Lian G, Lu J, Hu J, Zhang J, Cross SH, Ferland RJ, Sheen VL. Filamin A Regulates Neural Progenitor Proliferation and Brain Size through Wee1-Dependent Cdk1 Phosphorylation. J. Neurosci., 32(22):7672-84, 2012.

Hsiao Y-C, Tuz K, Ferland RJ, Trafficking in and to the primary cilium. Cilia, 1:4 (1-13), 2012

Westfall (Doering) JE, Hoyt C, Liu Q, Hsiao Y-C, Pierce EA, Page-McCaw PS, Ferland RJ. Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1. J. Neurosci., 30(26):8759-8768, 2010.

Papandrea D, Kukol WS, Anderson TM, Herron BJ, Ferland RJ. Analysis of flurothyl-induced myoclonus in inbred strains of mice. Epil. Res., 87:130-136, 2009.

Hsiao Y-C, Tong ZJ, Westfall (Doering) JE, Ault JG, Page-McCaw PS, Ferland RJ. Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for proper localization of Rab8a, ciliogenesis, and vesicular trafficking. Hum. Mol. Genet., 18(20):3926-3941, 2009.

Ferland RJ, Batiz LF, Neal J, Lian G, Bundock E, Lu J, Hsiao Y-C, Diamond R, Mei D, Banham A, Brown PJ, Vanderburg CR, Joseph J, Hecht JL, Folkerth R, Guerrini R, Walsh CA, Rodriguez EM, Sheen VL. Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. Hum. Mol. Genet., 18(3):497-516, 2009.

Papandrea D, Anderson TM, Herron BJ, Ferland RJ. Genetic dissociation of seizure traits in inbred strains of mice using the flurothyl model of epileptogenesis. Exp. Neurol., 215:60-68, 2009.

Morrow EM, Yoo S-Y, Flavell SW, Kim T-K, Lin Y, Hill RS, Mukaddes NM, Balkhy S, Gascon G, Hashmi A, Al-Saad S, Ware J, Joseph RM, Greenblatt R, Gleason D, Ertelt JA, Apse KA, Bodell A, Partlow JN, Barry B, Yao H, Markianos K, Ferland RJ, Greenberg ME, Walsh CA. Identifying autism loci and genes by tracing recent shared ancestry. Science, 321:218-223, 2008.

  • This work was highlighted in F1000 Prime, 31 Jul 2008.

Doering JE, Kane K, Hsiao Y-C, Yao C, Shi B, Slowik A, Dhagat B, Scott D, Ault JG, Page-McCaw PS, Ferland RJ. Species differences in the expression of AHI1, a protein implicated in the neurodevelopmental disorder Joubert syndrome, with preferential accumulation to stigmoid bodies. J. Comp. Neurol., 511:238-256, 2008.

Ferland RJ, Eyaid W, Collura RV, Tully LD, Hill RS, Al-Nouri D, Al-Rumayyan A, Topcu M, Gascon G, Bodell A, Shugart YY, Ruvolo M, and Walsh CA. Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert Syndrome. Nature Genet., 36:1008-1013, 2004.

OTHER SCHOLARLY ACTIVITY

Book Chapters:

Löscher W, Ferland RJ, Ferraro TN. Strain effects on expression of seizures and epilepsy. In: Models of Seizure and Epilepsy, 2nd edition, Cambridge: Academic Press (2017) pp. 21-38.  ISBN 9780128040669

Hua K, Bourgeois JR, Ferland RJ. Joubert syndrome. In: Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier (2017) pp. 1-8.   ISBN 9780128093245

Ferland RJ, Walsh CA. The genetics of Joubert syndrome: Insights into the development of the posterior midline of the brain.  In: Squire, LR (Ed.) Encyclopedia of Neuroscience.  San Diego: Academic Press (2009) pp. 249-256.

Applegate CD, Burchfiel JL, Ferland RJ, Nierenberg J.   The role of rhinencephalic networks in the late stages of kindling.  In: Corcoran, M and Moshe, S (Eds.) Kindling 5.  New York: Raven Press  (1998)  pp. 151-165.

Invited Editorials:

Ferland RJ and Guerrini R.  Nodular heterotopia is built upon layers. Neurology, 73: 742-743, 2009.

Ferland R and Hua K. Referee Report For: Murine Cep290 phenotypes are modified by genetic backgrounds and provide an impetus for investigating disease modifier alleles [version 1; referees: 2 approved] F1000Research 2015, 4:590 (doi: 10.5256/f1000research.7495.r10185)

Hua K and Ferland RJ. Primary cilia: the story of the hair-like organelle that signals just became more complicated. Atlas of science, 2019. https://atlasofscience.org/primary-cilia-the-story-of-the-hair-like-organelle-that-signals-just-became-more-complicated/

Ramaz Geguchadze, PhD
  • Research Assistant Professor
  • rgeguchadze@une.edu
  • Interests:

Publications:

Exploring mechanisms of increased cardiovascular disease risk with antipsychotic medications: Risperidone alters the cardiac proteomic signature in mice.  Beauchemin M, Geguchadze R, Guntur AR, Nevola K, Le PT, Barlow D, Rue M, Vary CPH, Lary CW, Motyl KJ, Houseknecht KL.  Pharmacol Res. 2020; 152:104589.

A Novel Mechanism for Zika Virus Host-Cell Binding.  Rieder CA, Rieder J, Sannajust S, Goode DGeguchadze R, Relich RF, Molliver DCKing TEVaughn JMay M.  Viruses. 2019; 11(12):1101.

James Georgitis, MD
  • Clinical Assistant Professor
  • jgeorgitis@une.edu
Diana Goode, PhD
  • Assistant Professor
  • dgoode@une.edu
  • Interests: Neuro-immune interactions in pain; HIV pathogenesis and peripheral neuropathy

Publications:

Regulation of mitochondrial function by Epac2 contributes to acute inflammatory hyperalgesia. Goode DJ and Molliver DCJ Neurosci. 2021; 41(13):2883-2898.

Phospho-substrate profiling of Epac-dependent protein kinase C activity.  Goode DJ, Molliver DC.  Mol Cell Biochem. 2019; 456(1-2):167-178.

A Novel Mechanism for Zika Virus Host-Cell Binding.  Rieder CA, Rieder J, Sannajust S, Goode DGeguchadze R, Relich RF, Molliver DCKing TEVaughn JMay M.  Viruses. 2019; 11(12):1101.

Eliza Grlickova-Duzevik, MD, PhD
  • Clinical Assistant Professor
  • egrlickovaduzevik@une.edu
  • Interests: Bioinformatics; Neuroscience; Molecular and cellular biology
Benjamin J. Harrison, PhD
  • Assistant Professor
  • bharrison2@une.edu
  • Interests: Neuroplasticity; Genomics; Bioinformatics

Publications:

Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs.  Harrison BJ, Park JW, Gomes C, Petruska JC, Sapio MR, Iadarola MJ, Chariker JH, Rouchka EC.  Front Genet. 2019; 10:182.

Neuropathy and neural plasticity in the subcutaneous white adipose depot.  Blaszkiewicz M, Willows JW, Dubois AL, Waible S, DiBello K, Lyons LL, Johnson CP, Paradie E, Banks N, Motyl K, Michael M, Harrison B, Townsend KL.  PLoS One. 2019; 14(9):e0221766.

Sean Kilgallen, MB, BCh, BAO
  • Clinical Associate Professor
  • skilgallen@une.edu
  • Interests: Medical education research

Publications:

Making the Connection: Using Concept Mapping to Bring the Basic Sciences to the Diagnosis.  Spicer DBThompson KHKilgallen SM.  J Am Osteopath Assoc. 2020; 120(8):524-528.

Karen L. Houseknecht, PhD
  • Professor; Associate Provost for Research
  • khouseknecht@une.edu
  • Interests: Integration of neuroscience/metabolism (diabetes); Efficacy & side effects of psychiatric medications and drugs of abuse; Treatment of metabolic syndrome, psychosis & pain-based diseases

Publications:

Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration.  Stefanucci A, Dimmito MP, Macedonio G, Ciarlo L, Pieretti S, Novellino E, Lei W, Barlow D, Houseknecht KL, Streicher JM, Mollica A.  J Med Chem. 2020; 63(5):2673-2687.

Exploring mechanisms of increased cardiovascular disease risk with antipsychotic medications: Risperidone alters the cardiac proteomic signature in mice.  Beauchemin M, Geguchadze R, Guntur AR, Nevola K, Le PT, Barlow D, Rue M, Vary CPH, Lary CW, Motyl KJ, Houseknecht KL.  Pharmacol Res. 2020; 152:104589.

Antipsychotic-induced immune dysfunction: A consideration for COVID-19 risk.  May M, Slitzky M, Rostama B, Barlow D, Houseknecht KL.  Brain Behav Immun Health. 2020; 6:100097.

Synthesis and Structure-Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects.  Vekariya RH, Lei W, Ray A, Saini SK, Zhang S, Molnar G, Barlow D, Karlage KL, Bilsky EJ, Houseknecht KL, Largent-Milnes TM, Streicher JM, Ananthan S.  J Med Chem. 2020; 63(14):7663-7694.

Deletion of α-Synuclein in Prrx1-positive cells causes partial loss of function in the central nervous system (CNS) but does not affect ovariectomy induced bone loss.  Figueroa CA, Bajgain P, Stohn JP, Hernandez A, Brooks DJ, Houseknecht KL, Rosen CJ.  Bone. 2020; 137:115428.

Association of Beta Blocker Use With Bone Mineral Density in the Framingham Osteoporosis Study: A Cross-Sectional Study. Lary CW, Hinton AC, Nevola KT, Shireman TI, Motyl KJ, Houseknecht KL, Lucas FL, Hallen S, Zullo AR, Berry SD, Kiel DP. JBMR Plus. 2020; 4(9):e10388.

Understanding Mechanisms Underlying Non-Alcoholic Fatty Liver Disease (NAFLD) in Mental Illness: Risperidone and Olanzapine Alter the Hepatic Proteomic Signature in Mice. Rostama B, Beauchemin M, Bouchard C, Bernier E, Vary CPH, May MHouseknecht KL. Int J Mol Sci. 2020; 21(24):E9362.

The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice.  May M, Beauchemin M, Vary C, Barlow D, Houseknecht KL.  PLoS One. 2019; 14(6):e0218937.

Polymicrobial abscess following ovariectomy in a mouse.   Eaton VE, Pettit S, Elkinson A, Houseknecht KLKing TEMay M.  BMC Vet Res. 2019; 15(1):364.

 

David W. Johnson, PhD
  • Associate Professor
  • Johnson@une.edu
Tamara King, PhD
  • Professor
  • tking6@une.edu
  • Interests: Mechanisms underlying cancer-induced bone pain and advanced osteoarthritis-induced pain

Publications:

Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels. Payne E, Harrington K, Richard P, Brackin R, Davis R, Couture S, Liff J, Asmus F, Mutina E, Fisher A, Giuvelis D, Sannajust S, Rostama B, King T, Mattei LM, Lee JJ, Friedman ES, Bittinger K, May M, Stevenson GW. J Pain. 2021 May 21:S1526-5900(21)00234-0.

Pros and Cons of Clinically Relevant Methods to Assess Pain in Rodents.  Tappe-Theodor A, King T, Morgan MM.  Neurosci Biobehav Rev. 2019; 100:335-343.

Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain.  Sannajust S, Imbert I, Eaton V, Henderson T, Liaw L, May M, Barbe MF, King T.  Pain. 2019; 160(9):2036-2049.

TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms.  Knight BE, Kozlowski N, Havelin J, King T, Crocker SJ, Young EE, Baumbauer KM.  Front Mol Neurosci. 2019; 12:220.

Polymicrobial abscess following ovariectomy in a mouse.   Eaton VE, Pettit S, Elkinson A, Houseknecht KLKing TEMay M.  BMC Vet Res. 2019; 15(1):364.

A Novel Mechanism for Zika Virus Host-Cell Binding.  Rieder CA, Rieder J, Sannajust S, Goode DGeguchadze R, Relich RF, Molliver DCKing TEVaughn JMay M.  Viruses. 2019; 11(12):1101.

Kin S. Ly, PharmD, EdD
  • Clinical Assistant Professor
  • kly@une.edu
  • Interests: Medical education research Research in Pharmacoeconomics
Meghan May, PhD
  • Professor
  • mmay3@une.edu
  • Interests: Pathogen evolution and genomics; Emerging infectious diseases; Mechanisms of infection-mediated pain; Improved clinical diagnostics for infections

Publications:

Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels. Payne E, Harrington K, Richard P, Brackin R, Davis R, Couture S, Liff J, Asmus F, Mutina E, Fisher A, Giuvelis D, Sannajust S, Rostama B, King T, Mattei LM, Lee JJ, Friedman ES, Bittinger K, May M, Stevenson GW. J Pain. 2021 May 21:S1526-5900(21)00234-0.

Emerging Infectious Diseases at the Clinic-Clinical Lab-Research Lab Interface. Anastasio N, Green E, Pettit S, May M. Annals of Pub Health Rep. 2021; 5(1):142-145.

Phenotypic diversity in an emerging mycoplasmal disease.  Perez K, Mullen N, Canter JA, Ley DH, May MMicrob Pathog. 2020; 103798.

Antipsychotic-induced immune dysfunction: A consideration for COVID-19 risk.  May M, Slitzky M, Rostama B, Barlow D, Houseknecht KL.  Brain Behav Immun Health. 2020; 6:100097.

Effects of the Covid-19 Pandemic on “The Big Three”: HIV, Tuberculosis, and Malaria. May M. Annals of Public Health Reports. 2020; 4(1).

Understanding Mechanisms Underlying Non-Alcoholic Fatty Liver Disease (NAFLD) in Mental Illness: Risperidone and Olanzapine Alter the Hepatic Proteomic Signature in Mice. Rostama B, Beauchemin M, Bouchard C, Bernier E, Vary CPH, May MHouseknecht KL. Int J Mol Sci. 2020; 21(24):E9362.

Role of Evolutionary Selection Acting on Vaccine Antigens in the Re-Emergence of Bordetella Pertussis.  Etskovitz H, Anastasio N, Green E, May M.  Diseases. 2019; 7(2):35.

Mechanism of Microbicidal Action of E-101 Solution, a Myeloperoxidase-Mediated Antimicrobial, and Its Oxidative Products.  Denys GA, Devoe NC, Gudis P, May M, Allen RC, Stephens JT Jr.  Infect Immun. 2019; 87(7):e00261-19.

The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice.  May M, Beauchemin M, Vary C, Barlow D, Houseknecht KL.  PLoS One. 2019; 14(6):e0218937.

Recommended rejection of the names Malacoplasma gen. nov., Mesomycoplasma gen. nov., Metamycoplasma gen. nov., Metamycoplasmataceae fam. nov., Mycoplasmoidaceae fam. nov., Mycoplasmoidales ord. nov., Mycoplasmoides gen. nov., Mycoplasmopsis gen. nov. [Gupta, Sawnani, Adeolu, Alnajar and Oren 2018] and all proposed species comb. nov. placed therein.  Balish M, Bertaccini A, Blanchard A, Brown D, Browning G, Chalker V, Frey J, Gasparich G, Hoelzle L, Knight T, Knox C, Kuo CH, Manso-Silván L, May M, Pollack JD, Ramírez AS, Spergser J, Taylor-Robinson D, Volokhov D, Zhao Y.  Int J Syst Evol Microbiol. 2019; 69(11):3650-3653.

Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain.  Sannajust S, Imbert I, Eaton V, Henderson T, Liaw L, May M, Barbe MF, King T.  Pain. 2019; 160(9):2036-2049.

Polymicrobial abscess following ovariectomy in a mouse.   Eaton VE, Pettit S, Elkinson A, Houseknecht KLKing TEMay M.  BMC Vet Res. 2019; 15(1):364.

A Novel Mechanism for Zika Virus Host-Cell Binding.  Rieder CA, Rieder J, Sannajust S, Goode DGeguchadze R, Relich RF, Molliver DCKing TEVaughn JMay M.  Viruses. 2019; 11(12):1101.

Transcriptional and pathological host responses to co-infection with virulent or attenuated Mycoplasma gallisepticum and low pathogenic avian influenza A virus in chickens.  Canter JA, Tulman ER, Beaudet J, Lee D, May M, Szczepanek SM, Geary SJ.  Infect Immun. 2019; 88(1): e00607-19.

Ian D. Meng, PhD
  • Professor; Director, Ctr – Biomedical Research Excellence (COBRE); Director, Ctr – Excellence in the Neurosciences
  • imeng@une.edu
  • Interests: Migraine headache; Medication overuse headache; Transformation of migraine headache to chronic daily headache; Chronic dry eye syndrome

Publications:

Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors. Mecum NE, Demers D, Sullivan CE, Denis TE, Kalliel JR, Meng ID. Sci Rep. 2020 Oct 14;10(1):17225.

Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV. Pain. 2020 Oct 15.

Progesterone Application to the Rat Forehead Produces Corneal Antinociception.  Meng ID, Barton ST, Goodney I, Russell R, Mecum NE.  Invest Ophthalmol Vis Sci. 2019; 60(5):1706-1713.

Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1.  Hatta A, Kurose M, Sullivan C, Okamoto K, Fujii N, Yamamura K, Meng ID.  J Neurophysiol. 2019; 121(6):2191-2201.

Evaluation of Corneal Damage After Lacrimal Gland Excision in Male and Female Mice.  Mecum NE, Cyr D, Malon J, Demers D, Cao LMeng ID.  Invest Ophthalmol Vis Sci. 2019; 60(10):3264-3274.

Derek Molliver, PhD
  • Professor
  • dmolliver@une.edu
  • Interests: Signal transduction and proteomics in chronic pain; Control of neuronal response properties through changes in modular signaling complexes; G protein-coupled receptor signaling pathways

Publications:

Regulation of mitochondrial function by Epac2 contributes to acute inflammatory hyperalgesia. Goode DJ and Molliver DCJ Neurosci. 2021; 41(13):2883-2898.

Phospho-substrate profiling of Epac-dependent protein kinase C activity.  Goode DJ, Molliver DC.  Mol Cell Biochem. 2019; 456(1-2):167-178.

A Novel Mechanism for Zika Virus Host-Cell Binding.  Rieder CA, Rieder J, Sannajust S, Goode DGeguchadze R, Relich RF, Molliver DCKing TEVaughn JMay M.  Viruses. 2019; 11(12):1101.

Peter Morganelli, PhD
  • Clinical Professor
  • pmorganelli@une.edu
Rebecca Rowe, PhD
  • Associate Professor
  • rrowe@une.edu
  • Interests: Medical education research

Publications:

USMLE Step-1 is Going to Pass/Fail, Now What Do We Do? Belovich AN, Bahner I, Bonaminio G, Brenneman A, Brooks WS, Chinn C, El-Sawi N, Haight M, Haudek SB, Ikonne U, McAuley RJ, McKell D, Rowe R, Taylor TAH, Vari RC. Med Sci Educ. 2021 Jun 4:1-6.

Admissions During the COVID-19 Pandemic: Navigating an Altered Landscape for Successful Selection of Future Healthcare Providers. Belovich AN, Bahner I, Bonaminio G, Brenneman A, Brooks WS, Chinn C, El-Sawi N, Haight M, Haudek SB, McAuley RJ, McKell D, Rowe R, Taylor TAH, Slivkoff MD, Vari RC. Med Sci Educ. 2021 Feb 23:1-4.

Evolution and Revolution in Medical Education: Health System Sciences (HSS). Rowe RJ, Bahner I, Belovich AN, Bonaminio G, Brenneman A, Brooks WS, Chinn C, El-Sawi N, Haudek SB, Haight M, McAuley R, Slivkoff MD, Vari RC. Med Sci Edu. 2020; 16:1-6.

Mark Schuenke, PhD
  • Professor and Associate Chair
  • mschuenke@une.edu
  • Interests: Anatomical and biomechanical relationships related to lumbopelvic pain; Peripheral nerve entrapment; Countermeasures to age-related muscle atrophy and diabetes

Publications:

Report on 7 Years’ Experience Implementing an Undergraduate Medical Curriculum for Osteopathic Medical Students Using Entrustable Professional Activities.  Reynolds TS, Frothingham C, Carreiro JE, Branda A, Schuenke MDTucker KLDaly FWillard FH.  J Am Osteopath Assoc. 2020; 120(8):529-539.

Form and Force Closure of the Sacroiliac Joints.  Vleeming A, Schuenke M.  PM R. 2019; 11(Suppl 1):S24-S31.

Kyle Scully, PhD
  • Clinical Assistant Professor
  • kscully3@une.edu
  • Interests: Prehospital emergency medicine; Natural products
Douglas B. Spicer, PhD
  • Associate Professor
  • dspicer@une.edu
  • Interests: Innovations in medical education; Active learning pedagogies in medical education

Publications:

Making the Connection: Using Concept Mapping to Bring the Basic Sciences to the Diagnosis.  Spicer DBThompson KHKilgallen SM.  J Am Osteopath Assoc. 2020; 120(8):524-528.

Medical biochemistry without rote memorization: multi-institution implementation and student perceptions of a nationally standardized metabolic map for learning and assessment.  Spicer DBThompson KH, Tong M, Cowan TM, Fulton TB, Lindsley JE. Med Sci Edu. 2019; 29(1):87-92.

Christoph Straub, PhD
  • Assistant Professor
  • cstraub@une.edu
  • Interests: Neuroscience; Neurophysiology; Microcircuits; Chronic pain

Publications:

Population imaging of neural activity in awake behaving mice.  Piatkevich KD, Bensussen S, Tseng HA, Shroff SN, Lopez-Huerta VG, Park D, Jung EE, Shemesh OA, Straub C, Gritton HJ, Romano MF, Costa E, Sabatini BL, Fu Z, Boyden ES, Han X.  Nature. 2019; 574(7778):413-417.

Joel M. Talsma, MS
  • Clinical Assistant Professor
  • jtalsma@une.edu
  • Interests:

Publications:

Osteopathic Manipulative Treatment for Low Back Pain.  Ponna V, Talsma J, Pierce-Talsma S.  J Am Osteopath Assoc. 2020; 120(6):e84-e85.

Hypertension: An Osteopathic Perspective.  Prieto H, Pena N, Shubrook JH, Talsma J.  The AAO Journal. 2020; 30(2): 27-34.

Osteopathic Manipulative Treatment for Inhaled Rib Somatic Dysfunction.  Koch J, Tsui C, Talsma J, Pierce-Talsma S.  J Am Osteopath Assoc. 2020 Jul 28.

Kathryn H. Thompson, PhD, RDN
  • Professor
  • kthompson@une.edu
  • Interests: Cognitive integration of basic and clinical sciences to improve learning and retention; Culinary medicine; Concept mapping, team based learning

Publications:

Making the Connection: Using Concept Mapping to Bring the Basic Sciences to the Diagnosis.  Spicer DBThompson KHKilgallen SM.  J Am Osteopath Assoc. 2020; 120(8):524-528.

Medical biochemistry without rote memorization: multi-institution implementation and student perceptions of a nationally standardized metabolic map for learning and assessment.  Spicer DBThompson KH, Tong M, Cowan TM, Fulton TB, Lindsley JE. Med Sci Edu. 2019; 29(1):87-92.

Advancing Nutrition Education, Training, and Research for Medical Students, Residents, Fellows, Attending Physicians, and Other Clinicians: Building Competencies and Interdisciplinary Coordination.  Van Horn L, Lenders CM, Pratt CA, Beech B, Carney PA, Dietz W, DiMaria-Ghalili R, Harlan T, Hash R, Kohlmeier M, Kolasa K, Krebs NF, Kushner RF, Lieh-Lai M, Lindsley J, Meacham S, Nicastro H, Nowson C, Palmer C, Paniagua M, Philips E, Ray S, Rose S, Salive M, Schofield M, Thompson K, Trilk JL, Twillman G, White JD, Zappalà G, Vargas A, Lynch C.  Adv Nutr. 2019; 10(6):1181-1200.

Kerry L. Tucker, PhD
  • Associate Professor
  • ktucker2@une.edu
  • Interests: Primary cilia and pain processing; Primary cilia and brain development and function; Mouse models of congenital heart defects

Publications:

Noninvasive Electrocardiography in the Perinatal Mouse.  Fitzsimons LA, Brewer VL, Forrester J, Moran AM, Tucker KL.  J Vis Exp. 2020; 160:e61074.

Report on 7 Years’ Experience Implementing an Undergraduate Medical Curriculum for Osteopathic Medical Students Using Entrustable Professional Activities.  Reynolds TS, Frothingham C, Carreiro JE, Branda A, Schuenke MDTucker KLDaly FWillard FH.  J Am Osteopath Assoc. 2020; 120(8):529-539.

Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s Disease.  Mustafa R, Kreiner G, Kamińska K, Wood AJ, Kirsch J, Tucker KL, Parlato R.  Front Cell Neurosci. 2019; 13:565.

RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats.  Huynh PN, Giuvelis D, Christensen S, Tucker KL, McIntosh JM.  Mar Drugs. 2019; 18(1):12.

James M. Vaughn, PhD
  • Professor
  • jvaughn@une.edu
  • Interests:

Publications:

A Novel Mechanism for Zika Virus Host-Cell Binding.  Rieder CA, Rieder J, Sannajust S, Goode DGeguchadze R, Relich RF, Molliver DCKing TEVaughn JMay M.  Viruses. 2019; 11(12):1101.

Frank H. Willard, PhD
  • Professor
  • fwillard@une.edu
  • Interests: Neurovascular anatomy of the cervical and lumbosacral spine; Myofascial and ligamentous support system of the lumbosacral spine and its dysfunction in patients with low back pain

Publications:

Report on 7 Years’ Experience Implementing an Undergraduate Medical Curriculum for Osteopathic Medical Students Using Entrustable Professional Activities.  Reynolds TS, Frothingham C, Carreiro JE, Branda A, Schuenke MDTucker KLDaly FWillard FH.  J Am Osteopath Assoc. 2020; 120(8):529-539.

Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability: Implications for Healing. Brezinski M, Willard F, Rupnick M.  Circulation. 2019; 140(23):1857-1859.