Polyphenol-mediated Inhibition of Staphylococcal biofilm formation.
The majority of bacterial infections are caused by biofilm-forming microbes. Since biofilms contribute to virulence, disease persistence and drug resistance, there is urgent need for anti-infection strategies directed at biofilm-forming pathogens. Our work examines the mechanisms by which polyphenolic compounds, commonly derived from terrestrial and marine natural sources, to impair biofilm formation by Staphylococcus epidermidis and Staphylococcus aureus, two leading causes of biofilm-associated nosocomial infections.