Three new FOAs to connect the dots
To encourage innovative research on the interactions between hallmarks of aging, NIA has issued three interconnected Funding Opportunity Announcements (FOAs), all with the due date of Oct. 11, 2022:
RFA-AG-23-012 Inter-Organelle Communication as a Platform to Interrogate the Interactions of Hallmarks of Aging (R01 Clinical Trial Not Allowed)
Contact sites where the membranes of cell organelles come together are critical hubs for the transfer of ions, metabolites, lipids, and proteins that have important roles in cellular aging. This FOA aims to deepen our mechanistic understanding of organelle communication and how it shapes the interactions of the hallmarks of aging.
RFA-AG-23-013 Mapping Interconnectivity Among Hallmarks of Aging Under Lifespan Modifications (R01 Clinical Trial Not Allowed)
This FOA is designed to discover whether there are hierarchies among the hallmarks that underlie different changes with age, or if there is a threshold beyond which the hallmarks and/or their interactions with one another become “tipping points” that beyond which the aging process cannot be reversed.
RFA-AG-23-015 Studies of Cytosolic DNAs in the Interactions of Aging Hallmarks (R01 Clinical Trial Not Allowed)
The accumulation of DNA in the cytosol (the fluid portion of a cell’s cytoplasm) has important associations with aging, cellular senescence, and decline of cellular and physiological functions. The goal of this FOA is to explore cytosolic DNAs as integrators of hallmark interactions and instigators of downstream events leading to age-related cellular and tissue deterioration.